IgA protease-producing bacteria

"Nice Strip of Ham"

  • Neisseria (N. gonorrhoeae, N. meningitidis)
  • Streptococcus pneumoniae
  • Haemophilus influenza

 

The major pathogens which can produce IgA proteases (extracellular enzymes capable of degrading IgA1) are Neisseria gonorrhoeae, N. meningitidis, Streptococcus pneumoniae, Haemophilus influenzae and bacteria associated with periodontal disease and dental plaque formation.

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Did you know?


imageImmunoglobulin A (IgA) is the second most common immunoglobulin in human serum (after IgG) and is the predominant immunoglobulin found in mucosal secretions.
imageIgA proteases act by cleaving the heavy chain of the human IgA1 at specific sites within a 16-amino acid proline-rich polypeptide in the hinge region. This sequence is not present in IgA2 which is, therefore, resistant to IgA proteases.

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