Effects via Mu opiate receptors

"SACRUM"

  • Sedation
  • Analgesia
  • Constipation
  • Respiratory depression
  • Euphoria
  • Miosis
4

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imageSubtypes: μ1, μ2, μ3 μ1:analgesia; μ2: respiratory depression, miosis, euphoria, reduced GI motility, physical dependence; μ3:possible vasodilation
imageLocated in brain, cortex (laminae III and IV), thalamus,striosomes, periaqueductal gray,rostral ventromedial medulla, spinal cord, substantia gelatinosa, peripheral sensory neurons, intestinal tract

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